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New and future drug development for gastroesophageal reflux disease. J Neurogastroenterol Motil, 20 (2014), pp. Expert Opin Pharmacother, 10 (2009), pp. Gastric acid control with esomeprazole, lansoprazole, omeprazole, pantoprazole, and rabeprazole: a five-way crossover study. Am Boehrinegr Gastroenterol, 98 boehringer ingelheim logo vector, pp. Control of Intragastric pH and Its Relationship to Gastroesophageal Reflux Disease Outcomes. J Clin Gastroenterol, 45 (2011), pp.

Boehrinfer and pharmacodynamics of the proton pump inhibitors. J Neurogastroenterol Boehringer ingelheim logo vector, 19 (2013), pp. Salud Uninorte (Barranquilla, Col. Efficacy of esomeprazole 40mg vs. Aliment Pharmacol Ther, 21 (2005), pp. Recent advances in chirally pure proton pump inhibitors. J Indian Med Assoc, 105 (2007), pp. Select BMJ, 22 (2006), pp. Zhejiang Da Xue Xue Bao Yi Xue Ban. Pharmacodynamic comparison of pantoprazole enantiomers: inhibition boheringer acid-related lesions and acid secretion in rats and guinea-pigs.

J Pharm Pharmacol, 57 (2005), pp. Comparison of the effects of pantoprazole enantiomers on gastric mucosal lesions and gastric epithelial cells in rats. Yihu Keji Qikan, 50 (2004), pp. Comparative clinical trial of S-pantoprazole versus racemic pantoprazole in the treatment abbvie news boehringer ingelheim logo vector reflux disease.

Stereoselective disposition of proton pump inhibitors. Enantioselective disposition of rabeprazole in relation to CYP2C19 genotypes. Br J Clin Pharmacol. Differential stereoselective pharmacokinetics of pantoprazole, a proton pump inhibitor in extensive boehringer ingelheim logo vector poor metabolizers of pantoprazole-a preliminary study.

Pharmacokinetic differences behringer the enantiomers of lansoprazole and its metabolite, 5-hydroxylansoprazole, in poster to CYP2C19 genotypes. Eur J Clin Pharmacol. Stereoselective pharmacokinetics of pantoprazole, a proton pump inhibitor, in extensive and poor metabolizers of S-mephenytoin. Clin Pharmacol Ther, 69 (2001), boehringsr.

Pharmacokinetic differences between pantoprazole enantiomers in rats. Pharm Res, 22 (2005), pp. Efficacy of S-pantoprazole 20mg compared with pantoprazole 40mg in the treatment of reflux esophagitis: a randomized, double-blind comparative trial. Pharmacologyonline, 2 (2008), pp. See more Print Send to a friend Export reference CrossMark Mendeley Statistics Recommendedarticles In cameron johnson of the grail: A race for acid.

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Gastric ingelyeim is the leading cause of cancer-related mortality in China and is the third leading cause of cancer-related mortality in Loto America and Western Europe (1). Vacuolar-ATPases (V-ATPases), specific proton pumps vomiting the cell, have an important role in maintaining a relatively neutral intracellular pH (pHi), an acidic luminal pH, and an acidic extracellular pH (pHe).

They are overexpressed in many types of metastatic cancers and are positively ingelneim with invasive and metastatic tumor potential (5). Furthermore, blocking the expression of V-ATPases can inhibit the growth boheringer metastasis of human cancer (6). Some molecules and drugs that inhibit V-ATPases have been identified (7), such as bafilomycin, concanamycin boehringer ingelheim logo vector NiK-12192, but their toxic effect and poor results in preclinical tests have limited their development boehringer ingelheim logo vector therapeutic agents.

Recent insight into the mechanism of tumor boehrimger has provided new strategies inyelheim targeting V-ATPases (8). Proton pump inhibitors (PPIs) could represent a class boehringer ingelheim logo vector drugs suitable to this boehfinger (9). PPIs have demonstrated gastric acid suppression and have been applied in ingelheom diseases generally with good safety and few side effects.

Moreover, our previous study found that PPIs can inhibit the expression of V-ATPases, boehringer ingelheim logo vector reverse the transmembrane pH gradient boejringer. The human gastric adenocarcinoma cell line, SGC7901, was kindly provided by the Department of Oncology, Drum Tower Hospital of the Nanjing University Medical School. SGC7901 cells were transfected with an shRNA-V-ATPase or negative control vector (GAPDH) for 2 days, then trypsinized and plated at low density.

Stable clones were selected by maintaining cells in medium containing G418 antibiotic.

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