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This medicine does not contain side leder, gluten, tartrazine or any other azo dyes. Mylan Health Pty Side leder Level 1, 30 The Bond 30-34 Hickson Road Millers Point NSW 2000 www. Excipients with known side leder lactose studies of herbal medicine. White, flat circular bevel edged tablet containing 4 mg of cyproheptadine hydrochloride.

Marked 'P4' on one side, scored on the other. Periactin (cyproheptadine hydrochloride) is a serotonin and histamine antagonist with anticholinergic and sedative effects. As an antiallergic and antipruritic.

Periactin has a wide range pneumonia is antiallergic and antipruritic activity and can be used successfully in the treatment of acute and chronic allergies and side leder, such side leder dermatitis (including neurodermatitis side leder neurodermatitis circumscripta), eczema, eczematoid dermatitis, dermatographism, mild local allergic reactions to insect bites, hay fever and other side leder rhinitis, perennial allergic and vasomotor rhinitis, allergic conjunctivitis due to inhalant allergens and foods, urticaria, angioneurotic oedema, side leder and side leder reactions, anogenital pruritus and pruritus of chickenpox.

Periactin may be used as therapy for anaphylactic reactions, adjunctive to adrenaline and other standard measures after the acute manifestations have been controlled. In migraine and vascular types side leder headache. Periactin has been reported to have beneficial effects in a significant number of patients diagnosed as having vascular types of headache, side leder as migraine and histamine cephalalgia.

Many patients who have not been able to obtain adequate relief from any other agent have reported amelioration of symptoms with Periactin. The characteristic headache and feeling of side leder may disappear within an hour or two after the first dose. Children under 2 years of age. There is no recommended dosage schedule for children under 2 years of age.

Dosage must be individualised. Since the antiallergic effect side leder a single dose usually lasts four to six hours, the daily requirement should be given in divided doses three times a day or as often as necessary side leder provide continuous relief. The therapeutic range side leder from 4 mg to 20 mg a day, the majority of patients requiring 12 mg to 16 mg a day.

An occasional patient side leder require as much as 32 mg a day for adequate relief. It is suggested that dosage be initiated with 4 mg three times a day and adjusted according to the size and response of the patient.

The dosage is not to exceed 32 mg a day. Children (7 - 14 years). The usual dosage is 4 mg three times a day. This dosage may be adjusted as necessary according to the size and response of the patient. If an additional dose is required, it should be taken preferably at bedtime. The dosage is not to exceed 16 side leder a day. Children (2 - 6 years). It is suggested that the dosage be initiated with 2 mg two or three times a day and adjusted as necessary according to the size and response of the patient.

If an side leder dose is side leder, it should be taken at bedtime. The total dosage is not to exceed 12 mg a day. For migraine and vascular types of headache. Relief is usually obtained in responsive patients with 2 doses (total 8 mg) and maintained side leder 4 mg every 4 to 6 hours. Cyproheptadine should not be used for therapy of an acute asthmatic attack. Newborn or premature infants. Because of the higher risk of antihistamines for infants generally, and for newborn and premature infants in particular, antihistamine value in health is contraindicated in nursing mothers.

Hypersensitivity to cyproheptadine and other drugs of similar chemical structure. Monoamine oxidase inhibitor therapy (see Section 4. Antihistamines should not be used to treat lower respiratory tract symptoms, including those of acute asthma. Antihistamines are more likely to cause dizziness, sedation, and hypotension in elderly patients. Safety and side leder in children below the age of two years have not been established. Overdose of antihistamines, particularly in infants side leder children, may produce hallucinations, central nervous system side leder, convulsions, respiratory and cardiac arrest, and side leder. Rarely, prolonged therapy with antihistamines may cause blood dyscrasias.

MAO inhibitors prolong and intensify the anticholinergic effects of antihistamines. Antihistamines may have additive effects with alcohol and other CNS depressants, e. Drugs with antiserotonin activity, side leder as cyproheptadine, may interfere with serotonin enhancing antidepressant drugs.

Cyproheptadine may cause a false positive test result for tricyclic antidepressant drugs when evaluating a drug screen (e. Reproduction studies have been side leder in rabbits, side leder, and rats at doses up to 32 times the human dose and have revealed no evidence of impaired fertility or harm to valtrex fetus due to cyproheptadine. There are, however, no adequate or well controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

Cyproheptadine at about 10 times the human dose had no effect on fertility in a two-litter study in rats or a two-generation side leder in mice. The use of any drug in pregnancy or in women side leder childbearing potential side leder that the anticipated benefit be weighed against possible hazards to the embryo or fetus.

It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Periactin, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother (see Section 4. Cyproheptadine may cause drowsiness and may increase the effects of alcohol. The side effects that appear frequently are drowsiness and somnolence.

Many patients who complain initially of drowsiness may no longer do so after the first three or four days of continuous administration. For information on the management of overdose, contact the Poison Information Centre on 13 11 side leder (Australia). Antihistamine overdosage reactions may vary from central nervous system depression or stimulation to convulsions, respiratory and cardiac arrest, and death, especially in infants and children. Treatment should be supportive and symptomatic.



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