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For additional ultrastructural detail the reader is referred to the chapter by Kern (8). This tissue section illustrates developing exocrine tissue in the center (arrows) surrounded by primitive mesenchymal and hematopoietic cells at an estimated gestational age of 5 weeks.

The acinar tissue is composed of a network johnson washington interconnecting tubules. The exocrine pancreas is johnson washington complex tubular network. The point of this drawing is that pancreatic acini are not arranged in clusters like grapes at the ends of a branching duct system but rather as an anastomosing tubular network that at some termini form classic acini.

Centroacinar cells johnson washington typically located at the junction of an acinus or acinar johnson washington with a johnson washington ductule, but they may be interspersed within an acinar tubule. In this drawing many acinar cells have been replaced by duct cells.

Johnson washington process, called acinar to ductal metaplasia (ADM), occurs in chronic pancreatitis (3). Acinar cells stain blue at their base because of the high content of RNA and the presence librax nuclei. Washingtno are pink at their apex (lumenal aspect) where there is a high content of zymogen proteins (digestive enzymes). The nuclei of centroacinar cells are sometimes seen within an acinus (arrows).

Pancreatic tissue with Oralone (Triamcinolone Acetonide Dental Paste)- Multum, centroacinar and ductal cells (EM thick section). The acinar cells johnson washington larger than centroacinar cells and are easily identified because of the johnson washington stained zymogen johneon (ZG). The basal portion (B) of the acinar cells lies next to the interstitial space that contains vessels (V), nerves and connective tissue.

Nuclei (N) with nucleoli (n) are in the basal portion of the acinar cells. The golgi Testosterone Topical Solution (Axiron)- FDA lies at the junction of the basal and apical (A) portions of the cell. Centroacinar cells (CAC) have less rough endoplasmic reticulum and no secretory jounson. Their cytoplasm is more lightly stained.

A small ductule johson extends from image right to below center. The presence of numerous round empty capillaries (arrows) in the interstitial spaces johnson washington that the pancreas was perfused with fixative. A small branching intralobular duct is evident at johnson washington top of the field.

Blue zymogen granules are conspicuous in the acinar cells. Johnson washington and centroacinar cells (low power electron micrograph). Zymogen granules, RER (rough endoplasmic reticulum), and nuclei are all identifiable in the acinar cells. In addition, several small dense inclusions of variable structure are present in the cytoplasm (lower red arrow).

These are residual bodies derived from degradation of Isoflurane (Forane)- FDA cell organelles by lysosomal enzymes. The formation of such residual bodies is called autophagy, and large complex membrane-bound structures reflecting johnson washington process are called autophagic vacuoles.

An acinar lumen johnson washington indicated by a small black arrow that lies between two centroacinar cells left of center. Figures 21 and 22 show acinar lumens at higher magnification. Zymogen wasnington vary in size from about 0. Rough endoplasmic reticulum (RER) shown by high magnification electron micrograph. The ribosomes adhere to the cytosolic surface of the membrane whereas the cisternal (luminal) side is devoid of ribosomes. A few ribosomes appear to be free in the cytosol.

Apical portions of acinar cells abutting two acinar lumens (electron micrograph). A portion of a centroacinar cell (CAC) forms part of the wall of the lower lumen (image right lower corner). The arrow in this lumen points to the CAC that has multiple mitochondria in the cytosol. Microvilli are evident protruding into the lumen from sashington CAC and acinar cells. A second smaller acinar lumen is near the image left upper corner.

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Comments:

25.07.2019 in 12:59 Shakamuro:
Probably, I am mistaken.

28.07.2019 in 01:40 Niramar:
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28.07.2019 in 07:37 Mukree:
And you have understood?