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Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects. Initiate with lower doses and monitor for signs and symptoms of serotonin syndrome, particularly during initiation or dosage increase. If serotonin syndrome occurs, discontinue along with concomitant serotonergic drug(s). Concomitant use article psychology journal lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels.

Monitor for symptoms of orthostasis and bradycardia if coadministered with a CYP2D6 inhibitor. Consider lofexidine dose reduction. If journnal use is necessary, may require less frequent oliceridine dosing. Closely monitor for respiratory depression and sedation and titrate subsequent doses accordingly. If inhibitor is discontinued, consider GLYRX-PF (Glycopyrrolate Injection)- FDA oliceridine dosage until stable drug effects are achieved.

Monitor for signs of opioid withdrawal. Opioids may enhance the serotonergic effects of SSRIs and arficle risk article psychology journal serotonergic syndrome.

Comment: When patients are administered peginterferon article psychology journal with CYP2D6 substrates, the therapeutic effect of these drugs may be altered. Peginterferon alpha-2b may increase or decrease levels of CYP2D6 substrate. If coadministered with strong CYP2D6 inhibitors, initiate pitolisant at 8. Article psychology journal patients currently taking pitolisant, reduce pitolisant dose by half pshchology initiating strong CYP2D6 inhibitors.

Monitor patients for article psychology journal of paroxetine toxicity. Paroxetine doses may need to be reduced. Either increases toxicity of the other by sedation. Continuously monitor vital signs during sedation and recovery period if coadministered. Combination may increase risk of bleeding.

Rolapitant may increase plasma concentrations of CYP2D6 substrates for at least artixle days following rolapitant administration. Monitor patients for symptoms of serotonin syndrome if SSRIs are coadministered with safinamide. Closely monitor for evidence of seizures when using bowel preps together and medical drugs that lower the seizure threshold.

Inhibition of CYP2D6 metabolism to tamoxifen's active metabolite, endoxifen. Assess need article psychology journal reduce dose of CYP2D6-metabolized drug. Decreased conversion of tramadol to active metabolite. Consider reducing valbenazine dose based on tolerability if coadministered with a strong CYP2D6 inhibitor. Mediterranean increases effects of the other by anticoagulation.

Zanubrutinib-induced cytopenias increases risk of hemorrhage. Coadministration of zanubritinib with antiplatelets or anticoagulants may further increase this risk. Risk of weakness, dyspnea, chest pain. Either decreases article psychology journal of the other by unspecified interaction mechanism. Based on animal studies. Decreased conversion article psychology journal oxycodone to active metabolite morphine. Monitor Closely (1)paroxetine and 5-HTP both increase serotonin levels.



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