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Centroacinar cells are typically located at the junction of an acinus or acinar tubule with a nettle leaf extract ductule, but they may be interspersed within an acinar tubule. In this drawing many acinar cells have been replaced by duct cells.

This process, called acinar to ductal metaplasia (ADM), occurs in chronic pancreatitis (3). Acinar cells nettle leaf extract blue at their base because of the high content of RNA and the presence of nuclei.

They are pink at their apex (lumenal aspect) where there is a high content of zymogen proteins (digestive enzymes). The nuclei of centroacinar cells are sometimes seen within an acinus (arrows). Pancreatic tissue with acinar, centroacinar and ductal cells (EM thick section).

The acinar cells are larger than centroacinar cells and are easily identified because of bcg injection darkly stained zymogen granules (ZG). The nettle leaf extract portion (B) of the acinar cells lies next to the interstitial space that contains vessels (V), nerves and connective tissue.

Nuclei (N) with nucleoli (n) extdact in the basal portion of the acinar cells. The golgi (G) lies at the junction of the basal and apical (A) portions of the cell. Centroacinar cells (CAC) have less rough endoplasmic reticulum and no secretory granules. Their cytoplasm is more lightly stained. A small ductule (D) extends from image right to below center. The presence of nettle leaf extract round empty capillaries (arrows) in the interstitial nettlw indicates that the pancreas was perfused with fixative.

A small branching intralobular duct is evident at the top of the field. Blue zymogen granules are conspicuous in the acinar cells. Acinar and centroacinar cells (low power electron micrograph). Zymogen granules, RER (rough endoplasmic reticulum), and nuclei are all identifiable in the nettle leaf extract cells.

In addition, several small dense inclusions of variable structure are present in the cytoplasm (lower red arrow). These are extratc bodies derived from degradation nettle leaf extract acinar cell nettle leaf extract by lysosomal enzymes. The formation of such residual bodies is called autophagy, and large complex membrane-bound structures reflecting this process are called autophagic vacuoles.

An acinar lumen is indicated by a small black arrow that lies between two centroacinar cells left of center. Figures 21 and 22 show acinar lumens at higher magnification. Zymogen granules vary in size from about 0. Rough endoplasmic reticulum (RER) shown by high nettle leaf extract electron micrograph. The ribosomes adhere to the cytosolic surface of the membrane whereas the cisternal (luminal) side is devoid of ribosomes.

A few ribosomes appear to be free in eztract cytosol. Apical portions of acinar cells abutting two acinar lumens (electron micrograph). A portion of a centroacinar cell (CAC) Zerviate (Cetirizine Ophthalmic Solution)- Multum part nettle leaf extract the wall of the lower lumen (image right lower corner).

Nettle leaf extract arrow in this lumen points to the CAC that has multiple mitochondria in the cytosol. Microvilli are evident protruding into the lumen from both CAC and acinar cells. A second smaller acinar lumen is near the image left upper corner. Zymogen granules are heavily stained so it is not possible to distinguish their membranes. RER is also evident in the acinar cells.

Apical domain neytle acinar cells is filled with zymogen granules (electron micrograph). The acinar cells abut a lumen near the center of the image. Microvilli protrude into the lumen.

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